(a) FTIR Spectrum of Propranolol pure drug

(b) FTIR Spectrum of Propranolol with Pectin

(c) FTIR Spectrum of Propranolol with Guar gum

(d) FTIR Spectrum of Propranolol with Xanthan gum
Figure 1: FT-IR Spectrums

(a) DSC spectrum of pure drug Propranolol

(b) DSC overlay spectrum of Propranolol with Pectin

(c) DSC spectrum of Propranolol and Guar gum

(d) DSC spectrum of Propranolol and Xanthan gum
Figure 2: Thermograms of DSC study

Figure 3: Effect of natural polymer concentration on In vitro release profile of Propranolol HCl Matrix tablets

Figure 4: In vitro drug release profile of Propranolol HCl matrix tablet

Figure 5: Physical changes in Pectin tablet during dissolution

Figure 6: Physical changes in Xanthan gum tablet during dissolution

Figure 7: Physical changes in Guar gum tablet during dissolution

Figure 8: Effect of natural polymer concentration on swelling behavior of Propranolol HCl matrix tablets

Ingredients
Formulations
PPT1
PPT2
PPT3
PGT1
PGT2
PGT3
PXT1
PXT2
PXT3
Propranolol HCl
40
40
40
40
40
40
40
40
40
Pectin
80
`100
140
--
--
--
--
--
--
Guar gum
--
--
--
80
100
140
--
--
--
Xanthan gum
--
--
--
--
--
--
80
100
140
Carbopol
40
80
80
40
80
80
40
80
80
Dicalcium posphate
50
50
50
50
50
50
50
50
50
Magnesium stearate
5
5
5
5
5
5
5
5
5
Talc
5
5
5
5
5
5
5
5
5
Total
250
300
350
250
300
350
250
300
350
Drug polymer ratio
1:2
1:2.5
1:3.5
1:2
1:2.5
1:3.5
1:2
1:2.5
1:3.5
Polymer: Carbopol ratio
1:0.5
1.5:1
1.75:1
1:0.5
1.5:1
1.75:1
1:0.5
1.5:1
1.75:1

Table 1: Formula of matrix tablet formulation

Formulation
Bulk density
Tapped density
Angle of  repose
Compressibility index (%)
PPT1
0.375±0.03
0.438±0.03
19.5±0.06
21.21±0.002
PPT2
0.366±0.01
0.445±0.02
19.97±0.02
21.42±0.002
PPT3
0.346±0.02
0.398±0.06
20.25±0.02
17.94±0.003
PGT1
0.423±0.03
0.437±0.02
20.44±0.03
10.71±0.001
PGT2
0.481±0.02
0.456±0.03
19.05±0.04
11.11±0.002
PGT3
0.358±0.02
0.344±0.03
18.74±0.05
6.06±0.002
PXT1
0.392±0.04
0.451±0.01
23.81±0.03
7.69±0.004
PXT2
0.491±0.05
0.425±0.02
20.2±0.06
8.01±0.005
PXT3
0.403±0.05
0.409±0.04
26.96±0.04
10.61±0.006

Table 2: Precompression Parameters of Propranolol HCl granules

Formulation
Thickness (mm)
Hardness (Kg/cm2)
Friability (%)
Weight variation (mg ± SD)
Drug content uniformity (%)
PPT1
2.99±0.00
5.4±0.4
0.76
240±0.044
95.37±0.10
PPT2
3.65±0.06
6.4±0.5
0.96
270±0.049
98.56±0.62
PPT3
4.43±0.01
7.5±0.6
0.89
340±0.041
95.85±0.38
PGT1
3.01±0.03
5.5±0.4
0.81
245±0.056
98.73±0.30
PGT2
3.28±0.03
7.5±0.5
0.90
292±0.053
97.14±0.70
PGT3
3.48±0.03
7.4±0.5
0.99
340±0.012
99.69±0.16
PXT1

3.12±0.02

6.5±0.5

0.77

235±0.056

100.2±0.04
PXT2
3.33±0.03
6.8±0.2
0.67
286±0.037
98.74±0.07
PXT3
4.21±0.04
5.5±0.5
0.78
342±0.043
96.58±0.26

Table 3: Post compression parameters of Propranolol HCl matrix tablets

Formulation
Zero order
First order
Higuchi’s
Peppa’s
Hixson Crowell
k0(h-1)
R2
k1(h-1)
R2
KH(h-1/2)
R2
N
R2
KHC(h-1/3)
R2
PPT1
4.924
0.979
0.110
0.847
22.68
0.936
2.374
0.965
-0.201
0.742
PPT2
4.998
0.987
0.112
0.895
24.25
0.919
1.889
0.971
-0.171
0.783
PPT3
4.503
0.980
0.092
0.840
21.02
0.902
1.881
0.977
-0.148
0.684
PGT1
3.947
0.925
0.069
0.741
17.43
0.812
1.011
0.911
-0.090
0.807
PGT2
3.898
0.923
0.066
0.774
17.61
0.797
1.823
0.973
-0.139
0.558
PGT3
3.730
0.918
0.059
0.796
16.77
0.784
1.927
0.967
-0.083
0.840
PXT1
3.772
0.897
0.064
0.684
16.61
0.783
2.051
0.941
-0.182
0.569
PXT2
4.155
0.918
0.078
0.808
18.82
0.813
1.833
0.976
-0.146
0.599
PXT3
4.066
0.929
0.069
0.797
18.23
0.789
1.932
0.974
-0.143
0.576

Table 4: Drug release kinetics of Propranolol HCL matrix tablets