Figure 1: The ratio of myocardial blood flow (MBF) to myocardial oxygen consumption (MVO2) at different locations within the innervated and denervated regions of the left ventricle. innervated: 0.95 ± 0.30, denervated: 1.15 ±0.33, p= 0.02

Figure 2: Inverse relationship between MBF in different sites within innervated myocardium and the local amount of the neurotransmitter as indicated by 11C-HED. Decrease in MBF (increased coronary vascular resistance at same tissue nor-adrenaline concentration) in chronically denervated compared with innervated myocardium. This shows super-sensitivity of resistance vessels (data from Rimoldi et al., [10]

Heart rate (beats/min)
Systolic BP (mmHg)
Diastolic BP (mmHg)
LVdP/dtmax (mmHg/sec)
Rate Pressure Product (mmHg*b/min)
Coronary Resistance (mmHg/ml/min)
Coronary Resistance (mmHg/ml/min)
innervated
denervated
82.3±29
143±23
82±18
2751±249
12334±5180
118±28
127±38
Table 1: Haemodynamic data from the 9 successful experiments using PET to measure coronary blood flow