Figure 1: Effect on oxidative stress markers in S-D rats

Photomicrograph showing central vein (CV); portal tract (T); sinusoids (S); hepatocytes (H).
Plate 1: Liver section of Control group (A)

Photomicrograph showing central vein wall fibrosis (FC); peri-portal inflammation (PI); fatty changes (FC)
Plate 2: Liver section of Treatment group (B)

Photomicrograph showing normal structure of hepatic venule (V); sinusoids (S); hepatocytes (H).
Plate 3: Liver section of Treatment group (C)

Photomicrograph showing normal Hepatocytes (H) appearing normal and radiating from the central vein
plate 4: Liver section of Treatment group (D)

Photomicrograph showing the Hepatocytes (H) appearing normal and radiating from the Central Vein (CV)
Plate 5: Liver section of Treatment group (E)

Photomicrograph showing normal appearance of hepatocytes with preservation of normal hepatic architecture.
Plate 6: Liver section of Treatment group (F)
Figure 2: Liver section of Treatment groups

Body Weight

Group

Initial Weight (g)

Final Weight (g)

A

148.00 ± 3.97

165.80 ± 5.35

B

169.80 ± 4.33

133.80 ± 4.79

C

150.20 ± 1.98

140.80 ± 2.63

D

163.00 ± 4.86

148.60 ± 3.57

E

156.00 ± 7.73

141.80 ±6.76

F

158.20 ± 4.02

146.40 ± 3.93

Table 1:Effect on body weight in S-D rats

STRESS MARKERS

GROUP A

GROUP B

GROUP C

GROUP D

GROUP E

GROUP F

MDA (µ/mg)

7.37±0.96 a

18.20±0.14 b

11.30±0.11 c

14.92±0.16 d

15.94±0.14 d

10.17±0.95 c

GSH (µ/mg)

76.87±8.53 a

36.57±2.44 b

92.09±17.24 a

50.67±2.14 c

63.90±11.86 a

72.44±3.63 a

SOD (µ/mg)

1.01±1.4 a

1.20±0.07 a

1.23±001 a

1.15±0.04 a

1.25±0.04 a

1.33±0.06 a

CAT (µ/mg)

4.1±0.02 a

2.10±0.01 b

3.73±0.04 a

3.5±0.03 a

3.7±0.02 a

3.8±0.01 a

Table 2:Effect on oxidative stress markers in S-D rats

ENZYMES

GROUP A

GROUP B

GROUP C

GROUP D

GROUP E

GROUP F

AST (IU/L)

119.17±2.39a

180.13±4.25 b

110.53±1.91 c

106.57±2.24 c

106.30±2.69 c

159.77±1.46 d

ALP (IU/L)

2.77±0.06a

6.66±0.35 b

2.48±0.13 a

5.98±0.82 b

4.99±0.44 b

7.78±0.16 c

ALT (IU/L)

91.52±1.18a

133.94±3.72 b

86.01±2.49 a

95.42±1.27 a

93.97±1.62 a

103.94±3.72 c

Table 3:Effect on Liver function test in S-D rats