Figure 1: A. Normal proximal tubules with back to back proximal tubules and plenty cytoplasm ( H&E, 40 X10). B. In addition to flattening and simplification of tubular epithelium, immunohistochemical staining for injured proximal tubules show confluent cytoplasm staining for CD133 (20 X10). C. Ischemia type of tubular injury with flattening and simplification of tubular epithelium (H&E, 40 X10). D. Toxic type of tubular injury shows vacuoles in flattened tubular epithelium (H&E, 40 X10).

Age (year)
Gender
Diagnosis
β2-Microglobulin (µg/L)
Serum creatinine (mg/dl)
Urine analysis
50
M
Lupus nephritis, Tubular injury (toxic)
0.31
0.64
83
M
Diabetic nephropathy, Tubular injury
0.33
1.00
53
F
Focal, segmental glomerulosclerosis
0.47
2.40
↑ Tubular cells
60
M
IgA nephropathy, Tubular injury
0.49
5.00
↑ Tubular cells, Hematuria
29
M
Renal Transplantation, Tubular injury
0.53
4.50
↑ Tubular cells, Hematuria
35
M
IgA nephropathy
0.54
2.90
↑ Tubular cells, Hematuria
49
M
Lupus nephritis
0.63
1.03
↑ Tubular cells
68
M
Focal, segmental glomerulosclerosis
0.69
1.15
Hematuria
44
F
Focal, segmental glomerulosclerosis
1.15
1.10
↑ Tubular cells, Hematuria
16
F
Focal, segmental glomerulosclerosis
1.60
2.00
↑ Tubular cells, Hematuria
52
F
Granuloma
1.89
0.70
↑ Tubular cells
50
M
IgA nephropathy
1.89
0.83
20
M
Normal
4.52
3.26
↑ Tubular cells
47
M
Focal, segmental glomerulosclerosis
5.36
1.18
↑ Tubular cells, Hematuria
47
M
Renal Transplantation
5.44
1.19
Hematuria
74
M
Focal, segmental glomerulosclerosis
6.23
1.50
Granular casts
63
F
Focal, segmental glomerulosclerosis
7.19
4.50
↑ Tubular cells, Hematuria
38
M
Diabetic nephropathy
7.87
3.00
Granular casts,
77
F
ANCA-associated glomerulonephritis
9.23
2.90
73
M
ANCA-associated glomerulonephritis
12.9
2.30
63
M
Diabetic nephropathy, Tubular injury (toxic)
16.1
6.00
↑ Tubular cells
42
M
Focal, segmental glomerulosclerosis,
29.8
1.70
Neutrophils
62
F
Focal, segmental glomerulosclerosis
35.9
7.10
↑ Tubular cells
68
F
Focal, segmental glomerulosclerosis
46.3
2.50
↑ Tubular cells
53
F
Acute interstitial nephritis
47.2
5.60
↑ Tubular cells
60
M
Acute interstitial nephritis
79.8
4.50
↑ Tubular cells
Table 1: Clinical Indices, Diagnosis, concentration of β2-Microglobulin, serum creatinine and urine analysis

CD133 (+)

CD133 (-)

Beta2 Microglobulin
Increase (30)

26

4

Beta2 Microglobulin
Normal (17)

6

11

Table 2: Correlation of Urinary β2-microglobulin and CD133 Staining