Figure 1: Nutritional therapy is essential for maintenance of Sirtuin 1 (Sirt 1) regulation of glucose, amyloid beta and nitric oxide metabolism. Sirt 1 inactivation is associated with mitophagy and inactivation of hepatic antimicrobial drug metabolism. In diabetes, geriatrics and Alzheimer’s disease individuals Sirt 1 regulation is essential to maintain antibiotic use with Sirt 1 inhibitors such as LPS that induces magnesium and zinc deficiency connected to antimicrobial inactivation in these individuals